In Silico and ADMET Studies of Spiro-Quinazoline Compounds as Acetylcholine Esterase Inhibitors Against Alzheimer’s Disease
The synthesized spiro[cycloalkane-1,2'-quinazoline derivatives (1-6) exhibited their notable potential as AChE inhibitors. The observed significant inhibitory activity suggested that these derivatives warrant further exploration as candidates for developing therapeutic agents in AChE inhibitory pathways. This study emphasizes the relevance of quinazoline derivatives in searching for novel treatments for neurological disorders, particularly associated with cholinergic dysfunction, and they could be a useful alternative therapeutic agent.
Authors
- Mohd Yusuf (ORCID: https://orcid.org/0000-0003-0927-8490)
- Mamdouh A. Allahyani (ORCID: https://orcid.org/0000-0001-7929-7748)
- Osama Abdulaziz
- Mohammad Asif (ORCID: https://orcid.org/0000-0002-9352-3462)
- Abdullah Yahya Abdullah Alzahrani (ORCID: https://orcid.org/0000-0001-5231-8932)
- Mazen Mohammed Almehmadi (ORCID: https://orcid.org/0000-0002-7580-8667)
- Shivani Verma (ORCID: https://orcid.org/0000-0002-1367-5299)
Institutions
- Taif University (SA)
- Glocal University (IN)
- Era's Lucknow Medical College and Hospital (IN)
- Graphic Era University (IN)
- King Khalid University (SA)
Publication Details
- Journal
- CNS & Neurological Disorders - Drug Targets
- Published
- 2024-10-25
- DOI
- https://doi.org/10.2174/0118715273315412241009092249
- Citations
- 7
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.75