A Comparison of Molecular Techniques for Improving the Methodology in the Laboratory of Pharmacogenetics

One of the most critical goals in healthcare is safe and effective drug therapy, which is directly related to an individual's response to treatment. Precision medicine can improve drug safety in many scenarios, including polypharmacy, and it requires the development of new genetic characterization methods. In this report, we use real-time PCR, microarray techniques, and mass spectrometry (MALDI-TOF), which allows us to compare them and identify the potential benefits of technological improvements, leading to better quality medical care. These comparative studies, as part of our pharmacogenetic Five-Step Precision Medicine (5SPM) approach, reveal the superiority of mass spectrometry over the other methods analyzed and highlight the importance of updating the laboratory's pharmacogenetic methodology to identify new variants with clinical impact.

Authors

Institutions

Publication Details

Journal
International Journal of Molecular Sciences
Published
2024-10-26
DOI
https://doi.org/10.3390/ijms252111505
Citations
2
Primary Topic
Pharmacogenetics and Drug Metabolism
Type
article
Field-Weighted Citation Impact
0.93
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A Comparison of Molecular Techniques for Improving the Methodology in the Laboratory of Pharmacogenetics

Catalina Sanz, Belén García‐Berrocal, D.H. Heredero Jung, María Jesús García-Salgado et al.
2 citations
International Journal of Molecular Sciences
Pharmacogenetics and Drug Metabolism
0.93
article

A Comparison of Molecular Techniques for Improving the Methodology in the Laboratory of Pharmacogenetics

Catalina Sanz, Belén García‐Berrocal, D.H. Heredero Jung, María Jesús García-Salgado, Marie Lenski, Guillaume Drevin, Elena Marcos-Vadillo, María Isidoro‐García, María Celsa Peña-Martín, Romain Larrue, Sandra Milagros Lorenzo-Hernández
article en
2 citations

Abstract

One of the most critical goals in healthcare is safe and effective drug therapy, which is directly related to an individual's response to treatment. Precision medicine can improve drug safety in many scenarios, including polypharmacy, and it requires the development of new genetic characterization methods. In this report, we use real-time PCR, microarray techniques, and mass spectrometry (MALDI-TOF), which allows us to compare them and identify the potential benefits of technological improvements, leading to better quality medical care. These comparative studies, as part of our pharmacogenetic Five-Step Precision Medicine (5SPM) approach, reveal the superiority of mass spectrometry over the other methods analyzed and highlight the importance of updating the laboratory's pharmacogenetic methodology to identify new variants with clinical impact.

International Journal of Molecular SciencesVol. 25(21)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Universidad de Salamanca (ES), Université de Lille (FR), Institut Pasteur de Lille (FR), Centre Hospitalier Universitaire de Lille (FR), Instituto de Investigación Biomédica de Salamanca (ES), Université d'Angers (FR)
Good health and well-being
Openalex Percentile: Top 24%
Pharmacogenetics and Drug Metabolism
0.93
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.