Genistein inhibited endocytosis and fibrogenesis in keloid via CTGF signaling pathways
This study indicated that genistein-induced p53 undergoes cell cycle arrest via the CTGF pathway-inhibited keloid cultured cells, and genistein suppressed the primary keloid cell migration, suggesting that our research provides a new strategy for developing drugs for treating keloids.
Authors
- Chih‐Ting Hsu
- Chu‐Chyn Ou (ORCID: https://orcid.org/0000-0002-9392-8515)
- Jiunn‐Liang Ko (ORCID: https://orcid.org/0000-0001-6855-9239)
- Sheau‐Chung Tang (ORCID: https://orcid.org/0000-0003-0459-1576)
- Chun-Te Lu
- Yu-Ping Hsiao (ORCID: https://orcid.org/0009-0006-4672-791X)
Institutions
- National Taichung University of Science and Technology (TW)
- National Yang Ming Chiao Tung University (TW)
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- Taiwan Semiconductor Manufacturing Company (Taiwan) (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12263-024-00758-1
- Citations
- 3
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.60
Funders
- Chung Shan Medical University
- Chung Shan Medical University Hospital