Cartilage Laser Engraving for Fast-Track Tissue Engineering of Auricular Grafts

In this study, the optimal engraving parameters were determined through the analysis of scanning electron microscopy (SEM) data, as follows: a laser power density of 5.5 × 10<sup>5</sup> W/cm<sup>2</sup>, an irradiation rate of 0.1 mm/s, a well radius of 60 μm, a distance between well centers of 200 μm, and a number of passes for each well of 20. After 1 week of in vitro cultivation, chondrocytes were located on the surface of the scaffolds, in the sockets and lacunae of decellularized cartilage. When implanted into animals, both cellular and acellular scaffolds were able to support cartilage in-growth and complete regeneration of the defect without clear boundaries with normal tissue. Nevertheless, the scaffolds populated with cells exhibited superior biocompatibility and were not subject to rejection, in contrast to cell-free constructs.

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Publication Details

Journal
International Journal of Molecular Sciences
Published
2024-10-27
DOI
https://doi.org/10.3390/ijms252111538
Citations
2
Primary Topic
Electrospun Nanofibers in Biomedical Applications
Type
article
Field-Weighted Citation Impact
0.35

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article

Cartilage Laser Engraving for Fast-Track Tissue Engineering of Auricular Grafts

Elena M. Yatsenko, Evgeny I. Isaev, Ekaterina I. Smirnova, Ilya Klabukov et al.
2 citations
International Journal of Molecular Sciences
Electrospun Nanofibers in Biomedical Applications
0.35
article

Cartilage Laser Engraving for Fast-Track Tissue Engineering of Auricular Grafts

Elena M. Yatsenko, Evgeny I. Isaev, Ekaterina I. Smirnova, Ilya Klabukov, Anastas Kisel, Dmitri Atiakshin, Denis Baranovskii, Елена Исаева, С. А. Иванов, А. Д. Каприн, В. А. Степанов, Grigory A. Demyashkin, Grigoriy V. Afonin, Petr Shegay
article en
2 citations

Abstract

In this study, the optimal engraving parameters were determined through the analysis of scanning electron microscopy (SEM) data, as follows: a laser power density of 5.5 × 10<sup>5</sup> W/cm<sup>2</sup>, an irradiation rate of 0.1 mm/s, a well radius of 60 μm, a distance between well centers of 200 μm, and a number of passes for each well of 20. After 1 week of in vitro cultivation, chondrocytes were located on the surface of the scaffolds, in the sockets and lacunae of decellularized cartilage. When implanted into animals, both cellular and acellular scaffolds were able to support cartilage in-growth and complete regeneration of the defect without clear boundaries with normal tissue. Nevertheless, the scaffolds populated with cells exhibited superior biocompatibility and were not subject to rejection, in contrast to cell-free constructs.

International Journal of Molecular SciencesVol. 25(21)
Peoples' Friendship University of Russia (RU), Sechenov University (RU), University of Basel (CH), University Hospital of Basel (CH), Medical Radiological Research Center (RU), National Research Nuclear University MEPhI (RU)
Russian Science Foundation
Openalex Percentile: Top 43%
Electrospun Nanofibers in Biomedical Applications
0.35
DOIOpen Access PDFOpenAlex
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