The silent predictors: exploring galectin-3 and Irisin’s tale in severe COVID-19
We analyzed serum levels of galectin-3 and irisin in 59 patients with severe COVID-19 and 30 healthy controls. Elevated galectin-3 levels were associated with increased risks of mortality, need for intensive care, and severe acute respiratory distress syndrome. The optimal cut-off value for galectin-3 was 13.47 ng/ml, with a sensitivity of 72.7% and specificity of 76.6%. Irisin levels did not differ significantly between survivors and non-survivors at admission or on the 3rd day post-admission, but approached significance on the 7th day. These findings suggest that galectin-3 could be a valuable prognostic biomarker for severe COVID-19 outcomes, while irisin's role remains to be clarified in further studies.
Authors
- Zoran Todorović (ORCID: https://orcid.org/0000-0001-8869-9976)
- Slobodan Јаnkovic (ORCID: https://orcid.org/0000-0002-1519-8828)
- Višeslav Popadić (ORCID: https://orcid.org/0000-0002-0992-7481)
- Marija Zdravković (ORCID: https://orcid.org/0000-0003-4059-0263)
- Nenad Govedarović (ORCID: https://orcid.org/0000-0001-6741-1494)
- Stevan Vujić (ORCID: https://orcid.org/0000-0001-9301-1240)
- Nikola Stevanović (ORCID: https://orcid.org/0000-0003-2083-8313)
- Valentina Nikolić (ORCID: https://orcid.org/0000-0001-7184-0670)
- Lazar Stоšić (ORCID: https://orcid.org/0000-0003-0039-7370)
- Jelica Andjelković
Institutions
- University of Kragujevac (RS)
- University of Nis (RS)
- University of Belgrade (RS)
- University Hospital Medical Center Bezanijska kosa (RS)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2024-10-27
- DOI
- https://doi.org/10.1186/s13104-024-06978-3
- Citations
- 3
- Primary Topic
- Amoebic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja