Divergence of variant antibodies following SARS-CoV-2 booster vaccines in myeloma and impact of hybrid immunity
Hematological malignancies are associated with an increased risk of complications during SARS-CoV-2 infections. Primary series or monovalent booster vaccines reduce disease severity, hospitalization, and death among multiple myeloma patients. We characterized virus-neutralizing and spike-binding antibody profiles following monovalent (WA1) or bivalent (WA1/BA.5) SARS-CoV-2 booster vaccination in MM patients. Bivalent vaccination improved the breadth of binding antibodies but not neutralization activity against contemporary variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
Authors
- Kelly E. Manning (ORCID: https://orcid.org/0000-0002-6262-1190)
- Bushra Wali (ORCID: https://orcid.org/0000-0001-9278-8744)
- Nisha S. Joseph (ORCID: https://orcid.org/0000-0003-4001-9622)
- Craig C. Hofmeister (ORCID: https://orcid.org/0000-0003-4816-1607)
- Ajay K. Nooka (ORCID: https://orcid.org/0000-0003-4165-6869)
- Sagar Lonial (ORCID: https://orcid.org/0000-0002-8322-9323)
- Mehul S. Suthar (ORCID: https://orcid.org/0000-0002-2686-8380)
- Jeffrey M. Switchenko (ORCID: https://orcid.org/0000-0002-5563-9325)
- Madison Ellis (ORCID: https://orcid.org/0000-0002-0325-5477)
- Renee Julia Manalo (ORCID: https://orcid.org/0000-0002-9880-2268)
- Kavita M. Dhodapkar (ORCID: https://orcid.org/0000-0003-0587-4172)
- Maryam I. Azeem (ORCID: https://orcid.org/0000-0002-4369-5637)
- Jonathan L. Kaufman (ORCID: https://orcid.org/0000-0002-5687-6429)
- Madhav V. Dhodapkar (ORCID: https://orcid.org/0000-0002-8249-5988)
- Alberto Moreno (ORCID: https://orcid.org/0000-0002-3031-7194)
Institutions
- Emory Healthcare (US)
- Emory University (US)
- Piedmont Cancer Institute (US)
- Aflac (United States) (US)
- Children's Healthcare of Atlanta (US)
- Winship Cancer Institute
- Emory National Primate Research Center
Publication Details
- Journal
- npj Vaccines
- Published
- 2024-10-27
- DOI
- https://doi.org/10.1038/s41541-024-00999-6
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Emory University
- Children's Healthcare of Atlanta
- National Institutes of Health
- Winship Cancer Institute
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases