CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury
Our proof-of-concept study demonstrates the therapeutic potential of FAP CAR-Ms in alleviating myocardial I/R and potentially opens new avenues for the treatment of a range of heart diseases that include a fibrotic phenotype.
Authors
- Jiahe Zhang
- Jianghua Shen (ORCID: https://orcid.org/0000-0002-4606-542X)
- Yang Zhao (ORCID: https://orcid.org/0000-0002-0856-2724)
- Jiawan Wang (ORCID: https://orcid.org/0000-0002-2199-0483)
- Yuan Hai-long (ORCID: https://orcid.org/0009-0006-3930-525X)
- Moshi Song (ORCID: https://orcid.org/0000-0001-9929-8975)
- Chuting He
- Wanrun Xie (ORCID: https://orcid.org/0009-0006-8440-1523)
- Shaolong Zhang (ORCID: https://orcid.org/0000-0003-1627-9918)
- Zeya Li (ORCID: https://orcid.org/0000-0003-1091-7798)
- Heng Du (ORCID: https://orcid.org/0009-0006-1950-9650)
- Chaofan Yang
- Jingdong Wu (ORCID: https://orcid.org/0000-0002-5536-7438)
- Anhua Lei
- Siqi Liu
- Hao Zhang (ORCID: https://orcid.org/0000-0001-9474-3195)
- Jin Zhang (ORCID: https://orcid.org/0000-0002-6359-4147)
- Yujing Li (ORCID: https://orcid.org/0000-0002-1963-3188)
- Xu Liu
- Yanan Zhou (ORCID: https://orcid.org/0000-0002-8170-7811)
- Pengfei Xu (ORCID: https://orcid.org/0000-0002-1903-138X)
- Yihong Cai (ORCID: https://orcid.org/0009-0008-4807-5892)
- Jinmiao Bi (ORCID: https://orcid.org/0000-0003-1366-5469)
- Yingxin Liang
- Yuhan Wang (ORCID: https://orcid.org/0000-0001-6451-1166)
Institutions
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- World Wide Web Consortium (US)
- Institute of Zoology (KZ)
- Zhejiang Radio and Television University (CN)
- Regenerative Medicine Institute (MX)
- Communication University of Zhejiang (CN)
- Center for Life Sciences (CN)
- Zhejiang Medicine (China) (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1161/circresaha.124.325212
- Citations
- 56
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 15.82