Intronic Variants in the MSH2 (rs2303426 and rs10179950) and PMS2 (rs2286681 and rs62456178) Genes Are Not Associated with Colorectal Cancer in Mexican Patients
The genotypic and allelic frequencies of the four variants are reported for the first time in Mexican patients with CRC. No association was found between gene variants and risk for CRC but there was a strong linkage disequilibrium between the loci of both <i>MSH2</i> and <i>PMS2</i> genes. None of the variants showed a possible repercussion on splicing.
Authors
- Melva Gutiérrez‐Angulo (ORCID: https://orcid.org/0000-0003-3848-8892)
- María de la Luz Ayala‐Madrigal (ORCID: https://orcid.org/0000-0001-8875-5624)
- José Miguel Moreno-Ortíz (ORCID: https://orcid.org/0000-0001-7555-9851)
- Ruth Ramírez-Ramírez (ORCID: https://orcid.org/0000-0002-9195-3346)
- Mirna Gisel González-Mercado (ORCID: https://orcid.org/0000-0002-5734-5988)
- Anahí González‐Mercado (ORCID: https://orcid.org/0000-0002-8005-1304)
- Anna Guadalupe López-Ceballos
- Manuel Alejandro Rico-Méndez
Institutions
- Universidad de Guadalajara (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Genes
- Published
- 2024-10-26
- DOI
- https://doi.org/10.3390/genes15111380
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Secretaría de Educación Pública
- Universidad de Guadalajara