Magnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p
Our research found that H-Ex has a good therapeutic effect on PSCI by increasing the expression of miR-1228-5p in PSCI, while H-Ex loaded with Spion-Ex exhibited more excellent effects on improving mitochondrial function and cognitive impairment under magnetic attraction, which can be used as a novel strategy for the treatment of PSCI.
Authors
- Wen-Pin Hu (ORCID: https://orcid.org/0000-0003-1826-7689)
- Xiaolan Zhu
- Lili Cai
- Qun Zhou (ORCID: https://orcid.org/0000-0002-2025-3414)
- Yuefeng Li (ORCID: https://orcid.org/0000-0001-8875-3610)
- Rui Du (ORCID: https://orcid.org/0000-0003-3736-7909)
- Hong Wei (ORCID: https://orcid.org/0000-0001-8785-3564)
- Yuhao Xu
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12951-024-02941-3
- Citations
- 20
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 7.73
Funders
- National Natural Science Foundation of China