Sex differences in sleep deficits in mice with an autism-linked Shank3 mutation
Overall, our study demonstrates sex differences in sleep architecture and homeostatic response to SD in adult Shank3<sup>∆C</sup> mice. Thus, our study demonstrates an interaction between sex and genotype in Shank3<sup>∆C</sup> mice and supports the use of the Shank3<sup>∆C</sup> model to better understand mechanisms contributing to the sex differences in insomnia in ASD in clinical populations.
Authors
- Hannah Schoch (ORCID: https://orcid.org/0000-0001-5527-0284)
- Lucı́a Peixoto (ORCID: https://orcid.org/0000-0002-8444-9600)
- Kaitlyn Ford (ORCID: https://orcid.org/0000-0003-3772-0223)
- Christine Muheim (ORCID: https://orcid.org/0000-0002-1010-2516)
- E Medina (ORCID: https://orcid.org/0000-0002-7942-7685)
- Michael J. Rempe (ORCID: https://orcid.org/0000-0001-7552-9548)
- Kristan Singletary
Institutions
- Washington State University Spokane (US)
- Washington State University (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s13293-024-00664-6
- Citations
- 4
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.37
Funders
- Simons Foundation Autism Research Initiative
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke