Dynamics of the human bile acid metabolome during weight loss
Bile acids (BA) are supposed to cause metabolic alterations after bariatric surgery (BS). Here we report the longitudinal dynamics of the human BA metabolome by LC-MS/MS after BS versus low calory diet (LCD) in two obesity cohorts over 12 months. Rapid and persistent oscillations of 23 BA subspecies could be identified with highly specific patterns in BS vs. LCD. TCDCA, GLCA, and TLCA represent most promising candidates for drug development.
Authors
- Hannah Belikan
- Ralph Burkhardt (ORCID: https://orcid.org/0000-0003-1924-1202)
- Thomas Karrasch (ORCID: https://orcid.org/0000-0001-6850-588X)
- Gerhard Liebisch (ORCID: https://orcid.org/0000-0003-4886-0811)
- Andréas Schäffler
- Sebastian Köhler (ORCID: https://orcid.org/0000-0002-5316-1399)
- Jörn Pons‐Kühnemann (ORCID: https://orcid.org/0000-0002-8211-4399)
- Andreas Schmid (ORCID: https://orcid.org/0000-0003-4054-1971)
- Leonie Schweitzer
- Daniel Steger
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- Giessen School of Theology (DE)
- University of Regensburg (DE)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1038/s41598-024-75831-1
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Deutsche Forschungsgemeinschaft