Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
These findings unveil a novel pathway by which lactic acidemia promotes macrophage-derived eCIRP release, which, in turn, mediates ZBP1-dependent PVEC PANoptosis in sepsis-induced ALI. This finding offers new insights into the molecular mechanisms driving sepsis-related pulmonary complications and provides potential new therapeutic strategies.
Authors
- Melanie J. Scott (ORCID: https://orcid.org/0000-0001-6864-5970)
- You-Tan Liu
- Timothy R. Billiar (ORCID: https://orcid.org/0000-0002-2949-0811)
- Patricia Loughran (ORCID: https://orcid.org/0000-0001-9375-1724)
- Yuehua Li (ORCID: https://orcid.org/0000-0001-8028-248X)
- Ting Gong (ORCID: https://orcid.org/0000-0001-9732-7162)
- Qingde Wang (ORCID: https://orcid.org/0000-0002-2482-7972)
- Jie Fan (ORCID: https://orcid.org/0000-0002-0090-2704)
Institutions
- University of Pittsburgh (US)
- VA Pittsburgh Healthcare System (US)
- Southern Medical University Shenzhen Hospital (CN)
- McGowan Institute for Regenerative Medicine (US)
Publication Details
- Journal
- Military Medical Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s40779-024-00574-z
- Citations
- 37
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 8.65
Funders
- Foundation for the National Institutes of Health
- University of Pittsburgh
- Science, Technology and Innovation Commission of Shenzhen Municipality