Modulation of persistent bladder pain in mice: The role of macrophage migration inhibitory factor, high mobility group box-1, and downstream signaling pathways
MIF and HMGB1, acting through TLR4 and RAGE, mediated persistent BHA, while TRIF might modulate its onset. Further exploration of downstream TLR4 signaling may uncover novel therapeutic targets for treating persistent bladder pain.
Authors
- Shaojing Ye (ORCID: https://orcid.org/0000-0003-3903-5967)
- Fei Ma (ORCID: https://orcid.org/0000-0002-2967-8013)
- Dlovan F.D. Mahmood
- Pedro L. Vera (ORCID: https://orcid.org/0000-0003-2785-7218)
Institutions
- University of Kentucky (US)
- Lexington VA Health Care System (US)
Publication Details
- Journal
- Bladder
- Published
- 2024-10-28
- DOI
- https://doi.org/10.14440/bladder.2024.0015
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- National Institutes of Health