Enantioselective Deoxygenative Amino-Cyanation of Carboxylic Acids via Ti-Multicatalysis
Carboxylic acids are valued synthetic building blocks that offer shelf life stability, structural diversity, and wide commercial availability. Despite the remarkable synthetic utility of carboxylic acids, a direct enantioselective deoxygenative functionalization of carboxylic acids remains rare. We present enantioselective deoxygenative amino-cyanation of carboxylic acids using a novel Ti<sup>IV</sup>-multicatalytic system that catalytically modified each C-O bond of carboxylic acid to C-C, C-N, and C-H bonds, generating enantio-enriched chiral α-amino nitriles (up to 98:2 er).
Authors
- Sher Muhammad
- Byoungmoo Kim (ORCID: https://orcid.org/0000-0002-1428-7896)
- Diego Rodriguez (ORCID: https://orcid.org/0000-0001-5972-1388)
- Giovani Gutierrez
- Jason A. Wilt
- Emily Girotti
Institutions
- Clemson University (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1021/acs.orglett.4c03244
- Citations
- 7
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Clemson University
- American Chemical Society Petroleum Research Fund
- Division of Chemistry
- Division of Equity for Excellence in STEM