A proteome-wide association study identifies putative causal proteins for breast cancer risk
We conducted the first breast-tissue-based PWAS and identified seven proteins associated with breast cancer, including five proteins not previously implicated. These findings help improve our understanding of the underlying genetic mechanism of breast cancer development.
Authors
- Michele L. Coté (ORCID: https://orcid.org/0000-0003-0312-1601)
- Qiuyin Cai
- Guochong Jia (ORCID: https://orcid.org/0000-0002-8455-1832)
- Jie Ping (ORCID: https://orcid.org/0000-0001-9907-5819)
- Shuai Xu (ORCID: https://orcid.org/0000-0002-7798-5720)
- Tianying Zhao (ORCID: https://orcid.org/0000-0002-0103-1867)
- Jill E. Henry (ORCID: https://orcid.org/0000-0002-0998-6481)
- Yongchao Dou (ORCID: https://orcid.org/0000-0001-9315-1155)
- Xingyi Guo (ORCID: https://orcid.org/0000-0001-5269-1294)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-8676-2425)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-1226-070X)
- Jirong Long (ORCID: https://orcid.org/0000-0002-7433-9766)
- Xiao-Ou Shu
Institutions
- Indiana University Health (US)
- Baylor College of Medicine (US)
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1038/s41416-024-02879-1
- Citations
- 6
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- Foundation for the National Institutes of Health
- Vanderbilt University
- National Institutes of Health