First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation
Here we describe for the first time, electrical recordings from the vagus nerve in awake drug-resistant epilepsy patients with an implanted vagus nerve stimulation (VNS) device. We found that the VNS device was able to activate both myelinated and unmyelinated fibers within the vagus nerve, which contributes to our understanding of how VNS works in the context of drug-resistant epilepsy.
Authors
- Mikaela Patros
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Shobi Sivathamboo (ORCID: https://orcid.org/0000-0003-4638-9579)
- Matteo Maria Ottaviani (ORCID: https://orcid.org/0000-0002-6354-3278)
- David Farmer (ORCID: https://orcid.org/0000-0002-6350-9379)
- Kegan Moneghetti (ORCID: https://orcid.org/0000-0001-9503-6660)
- Vaughan Gary Macefield (ORCID: https://orcid.org/0000-0003-3325-6566)
- Hugh D. Simpson (ORCID: https://orcid.org/0000-0001-8695-1904)
Institutions
- Marche Polytechnic University (IT)
- The Royal Melbourne Hospital (AU)
- Baker Heart and Diabetes Institute (AU)
- The Alfred Hospital (AU)
- Alfred Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1002/epi4.13083
- Citations
- 7
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 1.73
Funders
- Jazz Pharmaceuticals
- LivaNova
- Eisai
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Neurological Disorders and Stroke
- UCB Pharma