Obesity-dependent selection of driver mutations in cancer
Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic ancestry. Obesity is therefore a driver of etiological heterogeneity in some cancers.
Authors
- Kelly R. Pekala (ORCID: https://orcid.org/0000-0002-8967-3388)
- Venise Jan Castillon
- Jian Carrot‐Zhang (ORCID: https://orcid.org/0000-0002-0103-9965)
- Nikolaus Schultz (ORCID: https://orcid.org/0000-0002-0131-4904)
- Tricia Park (ORCID: https://orcid.org/0000-0003-4471-004X)
- Chris Fong (ORCID: https://orcid.org/0000-0003-4672-0364)
- Alexander Gusev (ORCID: https://orcid.org/0000-0002-7980-4620)
- Sonia Boscenco
- Irina Ostrovnaya (ORCID: https://orcid.org/0000-0003-1783-0070)
- Justin Jee (ORCID: https://orcid.org/0000-0001-9783-0139)
- Ed Reznik (ORCID: https://orcid.org/0000-0002-6511-5947)
- Michele Waters (ORCID: https://orcid.org/0000-0002-5416-5172)
- A. Ari Hakimi (ORCID: https://orcid.org/0000-0002-0930-8824)
- Susie Kim (ORCID: https://orcid.org/0000-0002-9213-887X)
- Cerise Tang
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Nature Genetics
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1038/s41588-024-01969-3
- Citations
- 15
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.28
Funders
- U.S. Department of Defense
- AstraZeneca
- Memorial Sloan-Kettering Cancer Center
- Society of Memorial Sloan Kettering
- National Institutes of Health