TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway
Taken together, our study suggests that TMEM106B knockdown mediates the ALP pathway, leading to a decrease in α-syn, providing a new direction and perspective for the regulation of autophagy in PD.
Authors
- Kunpeng Qin
- Ren Ji-wen
- Binghui Hou (ORCID: https://orcid.org/0009-0009-1710-3579)
- Anmu Xie
- Kaixin Dou (ORCID: https://orcid.org/0000-0002-6677-3511)
- Yumei Liu (ORCID: https://orcid.org/0000-0002-7344-2796)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.bbadis.2024.167553
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China