Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells
Collectively, this study not only elucidates the oncogenic role of BCAT1 and its downstream SHOC2-RAS-ERK signaling axis in TNBC progression but also opens up avenues for potential therapies targeting BCAT1 or BCAA metabolism (using EB alone or in combination with its inhibitor candesartan) for TNBC treatment.
Authors
- Ronghua ZhuGe (ORCID: https://orcid.org/0000-0002-3114-9655)
- Yin‐Kwan Wong (ORCID: https://orcid.org/0000-0003-2813-488X)
- Huan Tang (ORCID: https://orcid.org/0000-0003-4772-9483)
- Ruixing Chen
- Ling Huang (ORCID: https://orcid.org/0000-0002-5135-6088)
- Jinjun Qian (ORCID: https://orcid.org/0000-0001-7650-3059)
- Wei Xiao (ORCID: https://orcid.org/0000-0001-7568-0782)
- Jigang Wang (ORCID: https://orcid.org/0000-0002-0575-0105)
- Guanjun Li
- Peili Wang (ORCID: https://orcid.org/0000-0002-3179-8364)
- Shijie Qin (ORCID: https://orcid.org/0009-0000-3592-1131)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5476-1524)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- National Clinical Research (US)
- Stomatology Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.jare.2024.10.021
- Citations
- 17
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- China Academy of Chinese Medical Sciences
- Science, Technology and Innovation Commission of Shenzhen Municipality
- National Key Research and Development Program of China