Anti-bacteria, anti-biofilm, and anti-virulence activity of the synthetic compound MTEBT-3 against carbapenem-resistant Klebsiella pneumoniae strains ST3984
The significant antimicrobial activity of MTEBT-3 against clinically isolated CRKP, along with its synergistic or additive effects with commonly used antibiotics, positions it as a promising candidate for treatment. Its ability to disrupt biofilm formation and reduce virulence factor expression further underscores its potential in managing CRKP infections.
Authors
- Donghong Yin
- Jinju Duan (ORCID: https://orcid.org/0000-0001-6175-5923)
- Xiaoman Zhao
- Binbin Li (ORCID: https://orcid.org/0009-0006-6219-3305)
- Shiyu Wang (ORCID: https://orcid.org/0000-0002-3237-5451)
- Yujie Liu (ORCID: https://orcid.org/0000-0002-8304-1451)
- Shuyun Wang (ORCID: https://orcid.org/0009-0000-2519-8875)
- Yan Song
- Jianbang Kang
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Institutions
- Shanxi Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Microbial Pathogenesis
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.micpath.2024.107068
- Citations
- 8
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Natural Science Foundation of Shanxi Province