PD-L1 Expression Varies in Thyroid Cancer Types and Is Associated with Decreased Progression Free Survival (PFS) in Patients with Anaplastic Thyroid Cancer
PD-L1 expression varies across different TC types and histological subtypes and may be modulated by the mutational landscape. PD-L1 expression in ATC is associated with shorter PFS. Follow up studies are warranted to elucidate the molecular mechanism driving the observed differences in immune pathways, potentially paving the way for the development of more effective and personalized immune therapies for patients with aggressive TC.
Authors
- Jennifer E. Rosen (ORCID: https://orcid.org/0000-0002-1030-0811)
- Leonard Wartofsky (ORCID: https://orcid.org/0000-0002-2183-6929)
- Deema Al-Souri (ORCID: https://orcid.org/0000-0001-7209-6812)
- Kenneth D. Burman (ORCID: https://orcid.org/0000-0001-8597-7213)
- Jiling Chou (ORCID: https://orcid.org/0000-0002-0552-0246)
- Leila Shobab (ORCID: https://orcid.org/0000-0002-6534-810X)
- Joanna Kłubo-Gwieździńska (ORCID: https://orcid.org/0000-0001-8633-4420)
- Liza Mathews (ORCID: https://orcid.org/0000-0002-9977-7631)
- Michael B. Atkins (ORCID: https://orcid.org/0000-0003-3901-9924)
- William Kuenstner (ORCID: https://orcid.org/0000-0002-7248-8012)
- Matthew McCoy (ORCID: https://orcid.org/0000-0001-7601-6963)
- Vasyl Vasko (ORCID: https://orcid.org/0000-0003-1404-8446)
- Wen Lee
- Gretchen K. Hubbard
- Sonam Kumari (ORCID: https://orcid.org/0000-0002-6052-9972)
Institutions
- MedStar Washington Hospital Center (US)
- National Institutes of Health (US)
- Uniformed Services University of the Health Sciences (US)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- MedStar Georgetown University Hospital (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Caris Life Sciences (United States) (US)
- MedStar Health (US)
Publication Details
- Journal
- Cancers
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3390/cancers16213632
- Citations
- 7
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.50