Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott
Seven new alkaloids [<b>1</b>, (±)-<b>2</b>, (±)-<b>3</b>, <b>4</b>, and <b>5</b>] and one new natural product (<b>6</b>), along with eight known analogues, were isolated from the tubers of <i>Pinellia pedatisecta</i> Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-<b>3</b>, <b>6</b>, and <b>9</b> exhibited significantly protective effects against A<i>β</i><sub>25-35</sub>-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).
Authors
- Yingjie Niu (ORCID: https://orcid.org/0000-0003-1829-1718)
- Xiaoke Zheng (ORCID: https://orcid.org/0000-0003-3671-231X)
- Di Lu
- Weisheng Feng (ORCID: https://orcid.org/0000-0002-5987-412X)
- Xu Chen (ORCID: https://orcid.org/0000-0003-3314-5006)
- Lan Chen (ORCID: https://orcid.org/0000-0003-0157-1326)
- Yanling Liu (ORCID: https://orcid.org/0000-0002-1799-8044)
- Yan-Gang Cao (ORCID: https://orcid.org/0000-0002-6744-5974)
- Fang-Ge Chi
- Kaili Ye
- Bing-Xian Zhao
Institutions
- Henan Bioengineering Technology Research Center (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2024-10-26
- DOI
- https://doi.org/10.3390/molecules29215059
- Citations
- 3
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40