Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma
This study offers a comprehensive analysis of the genetic and immune profiles in LUAD primary tumors with LN metastasis, identifying key immunogenomic patterns linked to metastatic progression. The predictive model derived from these insights marks a substantial advancement in personalized treatment, underscoring its potential to improve patient management.
Authors
- Kaicheng Tang
- Fan Yang (ORCID: https://orcid.org/0000-0002-1044-7821)
- Fanjie Meng
- David P. Carbone (ORCID: https://orcid.org/0000-0003-3002-1921)
- Sida Cheng (ORCID: https://orcid.org/0000-0003-1591-9581)
- Jianpeng Sheng (ORCID: https://orcid.org/0000-0002-5535-5541)
- Olga Chervova (ORCID: https://orcid.org/0000-0002-1671-9488)
- Yaxing Zhao
- Hao Li (ORCID: https://orcid.org/0000-0001-9426-9446)
- Xiao Li (ORCID: https://orcid.org/0000-0001-8527-4438)
- Bin Hu (ORCID: https://orcid.org/0000-0003-3514-5413)
- Jun Wang (ORCID: https://orcid.org/0000-0002-7033-5012)
- Hao Luo (ORCID: https://orcid.org/0000-0002-9320-6766)
- Peiyu Wang (ORCID: https://orcid.org/0000-0002-7021-3939)
- Airong Yang
- Kezhong Chen (ORCID: https://orcid.org/0000-0002-9723-6153)
- Yun Li (ORCID: https://orcid.org/0009-0002-5707-5647)
- Ruoyi Jin
Institutions
- Army Medical University (CN)
- Peking University (CN)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- London Cancer (GB)
- Daping Hospital (CN)
- Peking University Cancer Hospital (CN)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- Peking University People's Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Infinity (United States) (US)
- University College London (GB)
- Nanjing University of Aeronautics and Astronautics (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s40164-024-00574-8
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Beijing Postdoctoral Science Foundation
- Chinese Academy of Medical Sciences
- Peking University
- Peking University People's Hospital