Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort
Our findings suggest that elevated PFOA in human milk is related to metabolomic profiles consistent with enlarged milk fat globule membranes and altered fatty acid metabolism. Further, our study supports the theory that PFAS share mammary epithelial membrane transport mechanisms with fatty acids and associate with metabolic markers of reduced milk production.
Authors
- Carin Huset (ORCID: https://orcid.org/0000-0002-4538-9326)
- Megan E. Romano (ORCID: https://orcid.org/0000-0003-4932-2492)
- Rachel Criswell (ORCID: https://orcid.org/0000-0001-7703-0062)
- Jennifer L. Meijer (ORCID: https://orcid.org/0000-0003-3100-1770)
- Lisa A. Peterson (ORCID: https://orcid.org/0000-0001-8715-4480)
- Margaret Rita Karagas (ORCID: https://orcid.org/0000-0002-6398-7362)
- Douglas I. Walker (ORCID: https://orcid.org/0000-0003-2912-398X)
- Brock C. Christensen (ORCID: https://orcid.org/0000-0003-3022-426X)
- Julia Anglen Bauer (ORCID: https://orcid.org/0000-0001-8516-6998)
Institutions
- Dartmouth College (US)
- University of Minnesota (US)
- Emory University (US)
- University of Minnesota Medical Center (US)
- Minnesota Department of Health (US)
Publication Details
- Journal
- Environmental Epidemiology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1097/ee9.0000000000000352
- Citations
- 1
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Institutes of Health
- NIH Office of the Director
- National Institute of General Medical Sciences
- National Institute of Environmental Health Sciences
- Common Fund