Suppressing Expression of SERPINE1/PAI1 Through Activation of GPER1 Reduces Progression of Vulvar Carcinoma
Based on the findings in this study, suppressing PAI1 expression in VC cells appears to reduce their progression and tumorigenic potential. Therefore, PAI1 could possibly function as an oncogene in VC. GPER1 appears to be a suitable target for suppressing PAI1 in VC.
Authors
- Carsten Gründker (ORCID: https://orcid.org/0000-0001-8828-7955)
- Julia Gallwas (ORCID: https://orcid.org/0000-0001-9640-1973)
- TAMMY DOELKER
Institutions
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2024-10-28
- DOI
- https://doi.org/10.21873/cgp.20473
- Citations
- 4
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.13