Impact of Mannitol Administration on Postoperative Renal Function After Robot-Assisted Partial Nephrectomy
<b>Background:</b> This study investigated the effect of mannitol administration on postoperative renal function during robot-assisted partial nephrectomy (RAPN) in patients with renal cell carcinoma (RCC). <b>Methods:</b> Patients with RCC who underwent RAPN at eight Japanese facilities between March 2016 and November 2023 were enrolled. In this study, patients were categorized into two groups according to those who received mannitol during RAPN (Group I) and those who did not receive mannitol (Group II). Differences in covariates between the two groups were adjusted using propensity score matching (PSM). <b>Results:</b> The study included 1530 patients with RCC who underwent RAPN. PSM was performed on 531 participants in each group. No difference was observed in perioperative outcomes between the two groups in terms of length of hospital stay, surgical outcomes, achievement ratio of Trifecta, and estimated glomerular filtration rate at 28 days, 90 days, and 1 year postoperatively. <b>Conclusions:</b> Intraoperative mannitol administration during RAPN for improving renal function may be unnecessary.
Authors
- Kiyoshi Setoguchi (ORCID: https://orcid.org/0000-0003-2298-7478)
- Kazutaka Saito (ORCID: https://orcid.org/0000-0002-7261-0188)
- Tatsuaki Yoneda (ORCID: https://orcid.org/0009-0003-1849-2883)
- Kentaro Muraoka (ORCID: https://orcid.org/0000-0001-6055-1857)
- K Nishikawa (ORCID: https://orcid.org/0000-0002-0320-977X)
- Takahiro Inoue (ORCID: https://orcid.org/0000-0002-7710-1526)
- Kazuhide Makiyama (ORCID: https://orcid.org/0000-0002-7449-2015)
- Takuya Koie (ORCID: https://orcid.org/0000-0002-2980-127X)
- Yoshinori Ikehata (ORCID: https://orcid.org/0000-0001-5079-2171)
- Suguru Oka (ORCID: https://orcid.org/0000-0003-3846-6925)
- Akira Fujisaki (ORCID: https://orcid.org/0000-0001-5204-2358)
- Tomoki Taniguchi (ORCID: https://orcid.org/0000-0002-2612-2191)
- Shinji Urakami (ORCID: https://orcid.org/0000-0003-3753-9950)
- Hiroshi Kitamura (ORCID: https://orcid.org/0000-0002-1592-931X)
- Shin Ebara
- Kazuki Taniguchi
Institutions
- Mie University (JP)
- Daiyukai General Hospital (JP)
- Seirei Hamamatsu General Hospital (JP)
- Dokkyo Medical University Saitama Medical Center (JP)
- Social Insurance Saitama Chuo Hospital (JP)
- Toranomon Hospital (JP)
- Gifu University (JP)
- University of Toyama (JP)
- Ebara (Japan) (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3390/jcm13216444
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42