30 Years of Kidney Biopsy Data in Western Mexico

Background: A kidney biopsy provides the best opportunity to establish the etiology of the Chronic Kidney Disease (CKD), thereby improving management and predicting prognosis. Methods: A retrospective study was conducted that included adult patients who underwent renal biopsy between 1990 and 2019, performed by nephrologists in 4 centers in western Mexico and analyzed by 2 nephropathologists. Results: In the 30 years of study, 1933 kidney biopsies were studied, FSGS was the most frequent finding in 28%, followed by Lupus Nephritis. Table 1. We found predominance of lupus nephritis in women and IgAN in men. Conclusion: In Western Mexico, FSGS is the most frequent histological findings. In the last two decades, we observed a increase in lupus nephritis, pauci-immune glomerulonephritis and tubulopathies, which could be related to changes in causal factors. In the last decade we also observed a greater number of kidney graft biopsies, compatible with the increase in the number of kidney transplants performed. We consider that the proportion of the chronic kidney disease burden constituted by glomerulonephritis would be illuminated by dissecting it through a comprehensive epidemiological approach. Histopathologic Diagnoses - 1990-2000 2001-2010 2011-2019 MCD 1 (0.9) 6 (1.9) 49 (4.1) FSGS 28 (25.5) 139 (44.8) 406 (34) MN 9 (8.2) 42 (13.5) 84 (7) IgA/HSP 1 (0.9) 16 (5.2) 104 (8.7) MPGN/C3GP 13 (11.8) 25 (8.1) 35 (2.9) Amyloid 3 (2.7) 4 (1.3) 34 (2.8) Diabetic GS 9 (8.2) 42 (13.5) 84 (7) LN 6 (5.5) 38 (12.3) 181 (15.2) Pauci-immune GN 2(1.8) 3 (1) 68 (5.7) TMA 0 1 (0.3) 9 (0.8) DDD 0 0 1 (0.1) C1q N 0 1 (0.3) 6 (0.5) Nodular GS 0 2 (0.6) 6 (0.5) Proliferative Mesangial GN (NOS) 42 (38.2) 18 (5.8) 2 (0.2) Post infectious GN 1 (0.9) 2 (0.6) 7 (0.6) Tubulointerstitial 2 (1.8) 4 (1.3) 71 (5.9) ATN 0 2 (0.6) 66 (5.5) Deposition 0 0 6 (0.5) Inespecific 0 0 5 (0.5)