Effect of Hypoxia on Siglec-7 and Siglec-9 Receptors and Sialoglycan Ligands and Impact of Their Targeting on NK Cell Cytotoxicity
Our findings point to the role of Siglec-sialylated glycan interactions in hypoxic stress-induced NK cell dysfunction and recommend the potential integration of the manipulation of this axis through the targeting of Siglecs in future cancer immunotherapy strategies.
Authors
- Christopher J. Scott (ORCID: https://orcid.org/0000-0002-7582-3808)
- Derek Kunimoto
- Lena Ho (ORCID: https://orcid.org/0000-0002-9358-621X)
- Michelle K. Greene (ORCID: https://orcid.org/0000-0003-2318-9320)
- Michael J. Tolentino (ORCID: https://orcid.org/0000-0003-4914-7356)
- Salem Chouaı̈b (ORCID: https://orcid.org/0009-0007-3228-6882)
- Husam Hussein Nawafleh (ORCID: https://orcid.org/0000-0001-7195-5101)
- Mohamed A. Genead
- Anitha Krishnan (ORCID: https://orcid.org/0000-0001-9581-7125)
- Nagwa Ahmed Zeinelabdin (ORCID: https://orcid.org/0000-0003-2120-737X)
Institutions
- Queen's University Belfast (GB)
- Gulf Medical University (AE)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-10-28
- DOI
- https://doi.org/10.3390/ph17111443
- Citations
- 1
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Gulf Medical University