Bibliometric Analysis of Renal Osteoporosis in Nondialysis-Dependent CKD

Background: Chronic kidney disease (CKD) can cause abnormalities in biochemical markers, particularly affecting bone mineral metabolism, leading to deterioration of bone health. To date, many CKD osteoporosis (OP) studies have focused primarily on dialysis patients. Skeletal health in non-dialysis CKD patients has not received sufficient attention, and only a limited number of studies have found a correlation between reduced BMD and poor renal prognosis in non-dialysis patients. Bibliometric analyses help us to take control of the history and current status of this research field, explore its hot trends, and provide some basis for future research on CKD OP. Methods: All research-based articles and reviews in the field of CKD OP from 2000 to 2023 were searched in the Web of Science database through a developed search strategy. Information from different countries, institutions, journals and scholars was analysed and their contributions compared using CiteSpace and VOSviewer software. Analyse the frequency and prominence of keywords to fully present the current state of research and trajectory of the field. Results: A bibliometric study of studies related to CKD OP in CKD between 2000 and 2023 reveals that the attention received by this field is increasing year by year. The leading countries, institutions and authors in this field are from Europe and the United States. Disorders of bone metabolism have been the focus of research into CKD OP since 2000. Future trends in CKD OP research may focus on the study of the effect of vitamin D dosage and treatment regimen on improving CKD OP Relationship between bone metabolism-related indicators such as intact Parathyroid hormone and FGF23 and CKD OP and fracture risk in CKD patients. A prospective study of new calcium mimetics in the field of CKD OP. Mechanistic studies on the mechanisms regulating indolyl sulfate-induced oxidative stress in osteoblasts and the exploration of Nrf2 as a target for the prevention of bone loss in CKD patients. Conclusion: CKD OP has received increasing attention, and research hotspots in recent years have focused on the exploration of risk factors, drug development and clinical treatment. For the risk of developing CKD OP in non-dialysis patients, age, advanced stage of renal failure (G5), and NBAP are risk factors, and overweight or obesity, 25-(OH)-vitamin D, and iPTH are protective factors.