A Multicenter Study on the Related Factors of Pathological Classification in Patients with Primary IgA Nephropathy

Background: The aim of this study is to analyze the correlation between pathological staging and clinical data of patients with primary IgA nephropathy. To find the influencing factors of pathologic staging in patients with IgA nephropathy. It is expected to intervene these factors at an early stage to provide clinical ideas for controlling renal pathological damage. Methods: Pathological typing and clinical data of a total of 204 patients diagnosed with IgA nephropathy by renal puncture biopsy and meeting the inclusion and exclusion criteria were collected from eight centers, including the First Affiliated Hospital of Kunming Medical University, Dali Prefecture People's Hospital, Baoshan City People's Hospital, Wulumu People's Hospital, Pu'er People's Hospital, the First People's Hospital of Anning City, Yuxi City People's Hospital, and the Armed Police Force General Hospital of Yunnan Province. The correlation between the pathologic typing and clinical data of these patients was analyzed. Results: 1.High urinary PH (P=0.040), high 24-hour urinary protein (P=0.013), and history of alcohol consumption (P=0.016) are independent risk factors for endocapillary hypercellularity (E) lesions. 2.High blood total bilirubin (P=0.013) and high blood C4 (P=0.004) are protective factors for segmental glomerulosclerosis (S) lesions.High blood urea nitrogen (P=0.006) is an independent risk factor for them. 3.High blood urea nitrogen (P=0.044) and high blood creatinine (P＜0.001) are independent risk factors for tubular atrophy/interstitial fibrosis (T) lesions. 4.High blood total bilirubin (P=0.046) is a protective factor for cellular or fibrocellular crescents (C) lesions. Conclusion: 1.High urinary PH, high 24-hour urinary protein, and history of alcohol consumption are independent risk factors in the typing of intracapillary hyperplasia (E). 2.High blood total bilirubin and high blood C4 are protective factors in the typing of segmental glomerulosclerosis(S). High blood urea nitrogen is an independent risk factor for it. 4.High blood urea nitrogen and high blood creatinine are independent risk factors in the typing of tubular atrophy/interstitial fibrosis (T). 5.High blood total bilirubin is a protective factor in the typing of cellular or fibrocellular crescents (C) lesions. Funding: Government Support – Non-U.S.