A Single-Center Descriptive Study on the Catheter Salvage Rate of Catheter-Related Bloodstream Infection Treated with Antibiotic Lock Therapy among Patients on Hemodialysis

Background: Catheter Related Bloodstream Infection is a common complication of hemodialysis patients with tunneled catheter as route of access for renal replacement therapy. Antibiotic lock therapy along with systemic antibiotics has been one of the treatments offered for CRBSI with aim of catheter salvage especially for patients with multiple access failure however no local studies has been published yet to determine the catheter salvage rate against catheter removal rate using antibiotic lock therapy. Methods: A retrospective and descriptive design to identify ESRD patients treated with antibiotic lock treatment in a single-center for bloodstream infections due to catheter use for 1 year study period. The demographic and clinical characteristics of the subjects were then compiled using Univariate Descriptive statistics. Results: Out of the 33 patients included in the study, 23 patients (66%) had catheter salvage while the remaining 11 (33%) had catheter removal. Findings revealed that there were no significant differences between the two groups in terms of age, sex distribution, comorbidities, or etiology of ESRD. Most prevalent microbial growths were Staph aureus and A. Baumanii. The presence of fever and discharge were significantly higher among catheter removal group. A trend towards lower mean platelet count was likewise seen. Catheter removal was significantly higher among patients given with Ciprofloxacin lock therapy. Conclusion: The collective understanding of the significant factors influencing catheter removal and salvage may help tailor more targeted interventions and better patient care. This study assessed the catheter salvage rate of patients receiving hemodialysis who have a catheter-related bloodstream infection treated with antibiotic lock treatment. This study sought to serve as a foundation for future research projects, policy proposals as well as plans to improve services to ESRD patients on hemodialysis with central line bloodstream infection.