Effect of Dialysis Dose on Nutritional Status of Patients on Hemodialysis

Background: Malnutrition is common among dialysis patients and impacts morbidity and mortality. Underdialysis causes malnutrition, but it is not known if high dialysis doses (Kt/V ≥1.65) lead to greater intradialytic nutrient loss, inflammation and protein catabolism. This study challenged the hypothesis that a higher dialysis dose increases the risk of malnutrition. Methods: This is a pilot, single-center, prospective cohort. Aidamea online Kt/V was averaged for 6 months and compared with the change in dry weight, body mass index (BMI), mid-upper arm circumference (MUAC) for anthropometrics, modified SGA score, albumin, blood urea nitrogen (BUN), creatinine, and total lymphocyte count (TLC) as laboratory parameters. Results: There is an inverse correlation between high Kt/V and anthropometric parameters and BUN. As Kt/V increases, it is more likely to have a BMI <18.5 (OR 2.6), SGA B (OR 1.19) and TLC <1500 (OR 1.07), and less likely to have albumin <3.4 (OR 0.25), though associations were not statistically significant. Conclusion: The discordant results may be due to the high sieving coefficient for albumin, adequate protein repletion, and use of a single-use dialyzer in the center. A longer observation period may be needed. Thus, it is essential to individualize the approach when interpreting each parameter.Patient Flow DiagramCorrelation of HD doses to Nutritional Parameters