HMGB1/TREM1 crosstalk between heat-injured hepatocytes and macrophages promotes HCC progression after RFA
RFA-induced thermal injury triggers HMGB1 release from HCs, driving macrophage M2 polarization and increasing the invasion ability of liver cancer cells. These findings reveal a potential therapeutic target for combating liver cancer recurrence following thermal ablation.
Authors
- Xing Lai (ORCID: https://orcid.org/0000-0002-2543-816X)
- Junke Li (ORCID: https://orcid.org/0000-0002-9957-5650)
- Qing Luo (ORCID: https://orcid.org/0000-0002-3687-6974)
- Guoqing Hong
- Jianping Gong (ORCID: https://orcid.org/0000-0002-5926-7944)
- Chunming Li (ORCID: https://orcid.org/0000-0003-4071-7471)
- Bin Xiong (ORCID: https://orcid.org/0000-0003-4024-0554)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1007/s00432-024-05996-9
- Citations
- 2
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.48