Quantitative lung ultrasound findings correlate with radial alveolar count in experimental bronchopulmonary dysplasia
We investigated the relationship between the degree of alveolarization and ultrasound-assessed lung aeration in a validated preterm rabbit model of experimental bronchopulmonary dysplasia (BPD). Lung ultrasound findings were heterogeneously abnormal and consisted of zones with interstitial, interstitial-alveolar or consolidated patterns. The median radial alveolar count was 10.1 [8.4-11.5], 7.8 [6.1-9] and 7.3 [1.8-10.1] in rabbits with interstitial, interstitial-alveolar or consolidated ultrasound pattern, respectively (overall p = 0.036). Alveolar count and lung ultrasound score were significantly correlated (ρ = - 0.044 (95%CI: - 1; - 0.143), p = 0.009; τ<sub>-b</sub> = - 0.362 (95%CI: - 0.6; - 0.1), p = 0.017).
Authors
- Gino Villetti
- Chiara Catozzi
- Danièle De Luca (ORCID: https://orcid.org/0000-0002-3846-4834)
- Matteo Storti
- Francesca Ricci (ORCID: https://orcid.org/0009-0008-3396-3774)
- Angelo Modena
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Université Sorbonne Paris Nord (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Istituto di Farmacologia Traslazionale (IT)
Publication Details
- Journal
- The Ultrasound Journal
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s13089-024-00389-y
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chiesi Farmaceutici