Meropenem-resistant Burkholderia pseudomallei: a concerning single case in Australia with no prior meropenem exposure
We report a case of cutaneous melioidosis in a 54-year-old male with a meropenem-resistant sub-population. He was empirically treated with episodic doxycycline and trimethoprim-sulfamethoxazole; however, the abscess re-accumulated. The patient had no prior exposure to meropenem. A sub-population of the isolate was meropenem resistant with an MIC >32 µg ml<sup>-1</sup> and the identification was re-confirmed as <i>Burkholderia pseudomallei</i>. Whole-genome sequencing with ARDaP analysis only revealed a resistance determinant to doxycycline and did not reveal a resistance determinant to meropenem. Furthermore, no carbapenemases were detected through multiple bioinformatics tools. To date, this is the first reported case in Australia of a <i>B. pseudomallei</i> isolate resistant to meropenem without previous carbapenem exposure.
Authors
- Buenafe Adams
- Ferris Satyaputra (ORCID: https://orcid.org/0000-0002-4232-7293)
- Matthew S. Glover (ORCID: https://orcid.org/0009-0003-9346-5121)
- Brian M. Forde (ORCID: https://orcid.org/0000-0002-2264-4785)
- Pirathaban Sivabalan (ORCID: https://orcid.org/0000-0001-8340-1050)
- Ian Gassiep (ORCID: https://orcid.org/0000-0003-3548-6963)
- Robert Norton (ORCID: https://orcid.org/0000-0003-3948-9272)
- Jaimie Frazer (ORCID: https://orcid.org/0000-0001-7405-4499)
Institutions
- The University of Queensland (AU)
- Royal Brisbane and Women's Hospital (AU)
- Townsville Hospital (AU)
- Mater Adult Hospital (AU)
Publication Details
- Journal
- Access Microbiology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1099/acmi.0.000619.v4
- Citations
- 6
- Primary Topic
- Burkholderia infections and melioidosis
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Menzies School of Health Research