<scp>STING</scp> ‐dependent induction of neutrophilic asthma exacerbation in response to house dust mite
Our study identifies that triggering STING in the context of asthma induces cell death by PANoptosis, fueling the flame of inflammation through a mixed Th1/Th2 immune response recapitulating the features of severe asthma with a prognostic signature of type 1 neutrophils.
Authors
- Milena Sokołowska (ORCID: https://orcid.org/0000-0001-9710-6685)
- Bernhard Ryffel (ORCID: https://orcid.org/0000-0003-2897-8230)
- Isabelle Maillet (ORCID: https://orcid.org/0009-0003-7964-5978)
- Yasmine Messaoud‐Nacer
- Urszula Radzikowska (ORCID: https://orcid.org/0000-0002-7341-9764)
- Sebastian Lennox Johnston (ORCID: https://orcid.org/0000-0003-3009-9200)
- Bernard Malissen
- Michael R. Edwards (ORCID: https://orcid.org/0000-0001-6837-0532)
- Elodie Culerier
- David J. Jackson (ORCID: https://orcid.org/0000-0002-2299-868X)
- Florence Savigny
- Dieudonnée Togbe (ORCID: https://orcid.org/0000-0001-6658-414X)
- Valérie Quesniaux (ORCID: https://orcid.org/0000-0003-2907-7995)
- Stéphanie Rose
- Gabriel V. L. da Silva
- Rania Boussad
- Chloé Veront
Institutions
- Université d'Orléans (FR)
- Centre National de la Recherche Scientifique (FR)
- Imperial College Healthcare NHS Trust (GB)
- Inserm (FR)
- Universidade de São Paulo (BR)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of Zurich (CH)
- Aix-Marseille Université (FR)
- Immunologie et Neurogénétique Expérimentales et Moléculaires (FR)
- CK-CARE (CH)
- King's College School (GB)
- Asthma UK (GB)
- Centre d’Immunologie de Marseille-Luminy (FR)
- Centre d'Immunophénomique
- Imperial College London (GB)
Publication Details
- Journal
- Allergy
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1111/all.16369
- Citations
- 13
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- National Institute for Health and Care Research
- Asthma and Lung UK
- Imperial College London
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Conseil Régional du Centre-Val de Loire
- Université de Recherche Paris Sciences et Lettres
- PHENOMIN
- Medical Research Council
- European Research Council