Association of MRI-based knee osteoarthritis structural phenotypes with short-term structural progression and subsequent total knee replacement
The subchondral bone phenotype and inflammatory phenotype were associated with the progression of joint space narrowing, osteophytes and sclerosis in 24 months, along with subsequent TKR in 108 months. Besides, additive effects of overlapped phenotypes were further determined. These phenotypes could serve as valuable screening tools for future clinical trials and provide guidance for risk evaluation.
Authors
- Guangming Tao (ORCID: https://orcid.org/0000-0002-1371-7735)
- Peihua Cao (ORCID: https://orcid.org/0000-0003-4269-3899)
- Donghong Guo
- Tianxing Wu
- Chengkai Wu
- Yukang Liu
- Zhixiang Cai (ORCID: https://orcid.org/0000-0003-2192-1186)
- Xiaoshuai Wang (ORCID: https://orcid.org/0000-0002-9511-5737)
- Baoer Wu
- Jia Li (ORCID: https://orcid.org/0000-0002-7564-1262)
- Zikun Xie
- Zikai Xing
- Ning Chen (ORCID: https://orcid.org/0009-0008-3926-5117)
Institutions
- Nanfang Hospital (CN)
- Guangzhou Chemistry (China) (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s13018-024-05194-w
- Citations
- 16
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.52
Funders
- U.S. Department of Health and Human Services
- Pfizer
- GlaxoSmithKline
- Novartis Pharmaceuticals Corporation
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Institutes of Health
- Basic and Applied Basic Research Foundation of Guangdong Province