Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis
Progerin accumulation during the aging process can lead to ER stress activation, which can suppress OPDLSC stemness via the ATF6/p53/p21 axis.
Authors
- Dongdong Fei (ORCID: https://orcid.org/0000-0002-6808-0233)
- Rui Li (ORCID: https://orcid.org/0009-0007-0894-1947)
- Xueling Ge (ORCID: https://orcid.org/0000-0001-8493-1977)
- Y Z Wang
- Qingyuan Ye (ORCID: https://orcid.org/0000-0001-7804-9726)
- Xige Zhang
- Yang Zhang (ORCID: https://orcid.org/0000-0002-3209-5118)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-6800-1275)
- Jinjin Wang (ORCID: https://orcid.org/0009-0009-0397-4517)
- Qintao Wang (ORCID: https://orcid.org/0000-0003-2261-2027)
- Jiyun Ji
Institutions
- Chinese PLA General Hospital (CN)
- Hainan General Hospital (CN)
- Stomatology Hospital (CN)
- Hainan 301 Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.jare.2024.10.029
- Citations
- 6
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China
- General Hospital of People’s Liberation Army