A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response
HCC is a leading and fast-rising cause of cancer-related death worldwide. Despite approval of novel therapies, the outcome of advanced HCC remains unsatisfactory. By developing a novel patient-derived tumor spheroid model recapitulating tumor heterogeneity and microenvironment, we provide new opportunities for HCC drug development and analysis of mechanism of action in authentic patient tissues. The application of the patient-derived tumor spheroids combined with other HCC models will likely contribute to drug development and to improve the outcome of patients with HCC.
Authors
- Hideki Ohdan (ORCID: https://orcid.org/0000-0002-9066-1288)
- Thomas F. Baumert (ORCID: https://orcid.org/0000-0002-8864-2168)
- Kazuaki Chayama (ORCID: https://orcid.org/0000-0002-5530-5341)
- Hiroshi Aikata (ORCID: https://orcid.org/0000-0002-3409-2156)
- Catherine Schuster (ORCID: https://orcid.org/0000-0001-7281-4511)
- Fabio Giannone (ORCID: https://orcid.org/0000-0001-5065-6962)
- Cloé Gadenne
- Émilie Crouchet
- Emanuele Felli (ORCID: https://orcid.org/0000-0002-6510-1457)
- Marie Parnot
- Marine A. Oudot (ORCID: https://orcid.org/0000-0001-7393-4697)
- Patrick Pessaux (ORCID: https://orcid.org/0000-0001-5635-7437)
- Sarah Durand
- Natascha Roehlen (ORCID: https://orcid.org/0000-0002-6653-8765)
- Antonio Saviano (ORCID: https://orcid.org/0000-0001-7585-472X)
- Nuno Almeida (ORCID: https://orcid.org/0000-0001-7768-244X)
- Hong Tuan Duong (ORCID: https://orcid.org/0009-0006-3628-0405)
Institutions
- Hiroshima University (JP)
- Inserm (FR)
- Institut Universitaire de France (FR)
- Hiroshima Prefectural Hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Université de Strasbourg (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101252
- Citations
- 6
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Institut National de la Santé et de la Recherche Médicale
- Université de Strasbourg
- Institut Universitaire de France
- RIKEN