Selective Monoborylation of Methane by a Mono Bipyridyl‐Nickel(II) Hydride Catalyst

Abstract We report the development of an earth‐abundant metal catalyst for methane C−H borylation. The post‐synthetic metalation of bipyridine‐functionalized zirconium metal‐organic framework (MOF) with NiBr 2 , followed by treatment with NaEt 3 BH affords MOF‐supported monomeric bipyridyl‐nickel(II) dihydride species via active site isolation. The heterogeneous and recyclable nickel catalyst selectively borylates methane at 200 °C using pinacolborane (HBpin) to afford CH 3 Bpin in 61 % yield with a turnover number (TON) up to 1388. The confinement of the active NiH 2 ‐species within the uniformly porous MOF allows selective monoborylation of methane via shape‐selective catalysis by preventing the formation of sterically encumbered overborylated products. Unlike MOF−Ni catalyst, its homogeneous control is almost inactive in methane borylation due to its intermolecular decomposition. Our mechanistic investigation, including spectroscopic, kinetic, and control experiments, as well as DFT calculations, revealed that stabilizing mononuclear bipyridyl‐nickel dihydride and diboryl species by MOF is crucial for achieving efficient methane borylation via turnover‐limiting σ‐bond metathesis. This work shows promise in designing MOF‐based abundant metal catalysts for the chemoselective functionalization of methane and other inert molecules into valuable chemicals.