Transcriptomic analysis of cellular senescence induced by ectopic expression of ATF6α in human breast cancer cells
Transcriptomic analyses and validation reveal the importance of the MAP2K1/2/GPAT4-DDIT3 pathway in driving cellular senescence following ATF6α ectopic expression in MCF-7 cells. This study contributes to our understanding of the initial molecular events underlying ER stress-induced cellular senescence in breast cancer cells, providing a foundation for exploring cell type- and stressor-specific responses in cellular senescence induction.
Authors
- Mi-Ryung Han (ORCID: https://orcid.org/0000-0003-1745-6461)
- Jeongwon Sohn (ORCID: https://orcid.org/0000-0003-2395-458X)
- Sohyun Bae (ORCID: https://orcid.org/0000-0002-0206-7108)
- Ju Won Kim (ORCID: https://orcid.org/0000-0001-5650-1224)
- Yesol Moon (ORCID: https://orcid.org/0000-0001-9039-9593)
- Yong-Jin Kim (ORCID: https://orcid.org/0000-0001-8728-6133)
- Yun Gyu Park (ORCID: https://orcid.org/0000-0003-2554-2845)
Institutions
- Incheon National University (KR)
- Korea University (KR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1371/journal.pone.0309749
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Ministry of Education
- National Research Foundation
- Incheon National University
- Korea University
- National Research Foundation of Korea