Magnetic vagus nerve stimulation ameliorates contrast-induced acute kidney injury by circulating plasma exosomal miR-365-3p
In summary, we demonstrated that mVNS can improve CI-AKI through enhanced autophagy and apoptosis inhibition, which depended on plasma exosomal miR-365-3p. Our findings highlight the therapeutic potential of mVNS for CI-AKI in clinical practice. However, further research is needed to determine the optimal stimulation parameters to achieve the best therapeutic effects.
Authors
- Wenwu Zhu
- Rui Duan (ORCID: https://orcid.org/0000-0002-0187-9331)
- Siyuan Bao
- Bing Han (ORCID: https://orcid.org/0000-0002-3523-0573)
- Jianfei Sun (ORCID: https://orcid.org/0000-0003-2204-0479)
- Tianyu Wu (ORCID: https://orcid.org/0000-0002-5574-423X)
- Kaiyan Chen (ORCID: https://orcid.org/0000-0001-7755-3074)
- Yuqiong Chen (ORCID: https://orcid.org/0000-0001-7592-5989)
- Yao Lu (ORCID: https://orcid.org/0000-0003-4180-194X)
Institutions
- Xuzhou Medical College (CN)
- Suzhou Municipal Hospital (CN)
- Xuzhou Central Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12951-024-02928-0
- Citations
- 11
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Natural Science Foundation of China