Severe co-infection caused by difficult-to-diagnose hypermucoviscous Klebsiella pneumoniae K1-ST82 in a patient with COVID-19: a case report
This is the first case of severe COVID-19-associated co-infection with a difficult-to-diagnose K. penummoniae strain. Notably, co-infection by the hmKp K1-ST82 clone exhibited atypical phenotypes, including stunted growth, non-lactose fermentation, urease-negative reaction, ampicillin susceptibility, and abnormal mucoviscosity, posing diagnostic challenges for clinical laboratories and impedes the identification of hvKp/hmKp. Delayed identification may worsen patient outcomes, highlighting the need for increased clinical awareness of such difficult-to-diagnose clones to prevent deterioration.
Authors
- Masahiko Kimura (ORCID: https://orcid.org/0000-0003-0361-3331)
- Shizuo Kayama
- Liansheng Yu (ORCID: https://orcid.org/0000-0002-3520-8907)
- Yo Sugawara (ORCID: https://orcid.org/0000-0002-9897-3905)
- Wataru Hayashi (ORCID: https://orcid.org/0000-0003-3430-8524)
- Sadatomo Tasaka (ORCID: https://orcid.org/0000-0003-4861-4143)
- Motoyuki Sugai (ORCID: https://orcid.org/0000-0001-9252-7739)
- Hiroyuki Hanada (ORCID: https://orcid.org/0000-0002-2139-3857)
- Masamichi Itoga (ORCID: https://orcid.org/0000-0002-9400-5245)
Institutions
- Hirosaki University (JP)
- National Institute of Infectious Diseases (JP)
- Hirosaki University Hospital (JP)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12879-024-10092-x
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.51
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science