Comparing Rituximab and Cyclophosphamide in Induction Therapy for Childhood‐Onset Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis: An <scp>ARChiVe</scp> Registry Cohort Study
This is the first study comparing CYC and RTX for induction in pediatric GPA and MPA. No significant differences were shown in rates of remission, severe adverse events, or organ damage. Limitations included lack of standardized treatment regimens, retrospectivity, and lack of longitudinal adverse drug-related event data.
Authors
- Paul Dancey (ORCID: https://orcid.org/0000-0001-5998-9608)
- Kelly L. Brown (ORCID: https://orcid.org/0000-0001-5385-3582)
- David A. Cabral (ORCID: https://orcid.org/0000-0003-1840-9210)
- Else S. Bosman (ORCID: https://orcid.org/0000-0001-6575-2084)
- Adam M. Huber (ORCID: https://orcid.org/0000-0002-6616-1689)
- Vidya Sivaraman
- Melissa E. Elder (ORCID: https://orcid.org/0000-0002-8820-5515)
- Brett Klamer (ORCID: https://orcid.org/0000-0002-8334-4831)
- Susan Shenoi (ORCID: https://orcid.org/0000-0002-2495-594X)
- Dirk Foell (ORCID: https://orcid.org/0000-0002-1946-3916)
- Alvaro Orjuela
- Rae S. M. Yeung (ORCID: https://orcid.org/0000-0003-2361-725X)
- Raju Khubchandani (ORCID: https://orcid.org/0000-0003-0294-119X)
- Samundeeswari Deepak (ORCID: https://orcid.org/0000-0003-3222-1441)
- Dana Gerstbacher (ORCID: https://orcid.org/0000-0001-7135-6766)
- Linda Wagner‐Weiner (ORCID: https://orcid.org/0000-0003-0932-2981)
- Charlotte Myrup (ORCID: https://orcid.org/0000-0001-6960-7466)
- Kimberly Morishita (ORCID: https://orcid.org/0000-0002-1389-4002)
- L. Nandini Moorthy (ORCID: https://orcid.org/0000-0001-9410-2099)
- Sirirat Charuvanij (ORCID: https://orcid.org/0000-0002-0506-6039)
- Kathryn Cook (ORCID: https://orcid.org/0000-0002-4490-9377)
- Flora McErlane (ORCID: https://orcid.org/0000-0002-2328-2122)
- B. Anne Eberhard
- Eslam Al‐Abadi (ORCID: https://orcid.org/0000-0002-1999-6341)
- Stacey E. Tarvin (ORCID: https://orcid.org/0000-0001-8583-7878)
- Samuel J Gagne (ORCID: https://orcid.org/0000-0002-3432-296X)
- Tamara Tanner
Institutions
- Rutgers, The State University of New Jersey (US)
- Indiana University Health (US)
- Seattle Children's Hospital (US)
- Dalhousie University (CA)
- Northwell Health (US)
- Nationwide Children's Hospital (US)
- Siriraj Hospital (TH)
- Lucile Packard Children's Hospital (US)
- Montefiore Medical Center (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- University of Toronto (CA)
- University of Münster (DE)
- Mahidol University (TH)
- Izaak Walton Killam Health Centre (CA)
- Hospital for Sick Children (CA)
- Janeway Children's Health and Rehabilitation Centre (CA)
- Johnson University (US)
- Copenhagen University Hospital (DK)
- Riley Hospital for Children (US)
- Nottingham City Hospital (GB)
- University of Florida (US)
- University of Chicago Medical Center (US)
- Akron Children's Hospital (US)
- Birmingham Children's Hospital (GB)
- Cohen Children's Medical Center (US)
- Children's Hospital of Pittsburgh (US)
- Montefiore Hospital (GB)
- Great North Children's Hospital (GB)
- St. John's School (US)
- SickKids Foundation (CA)
- Texas Children's Hospital (US)
- BC Children's Hospital (CA)
- SRCC Children’s Hospital (IN)
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- Newcastle University (GB)
Publication Details
- Journal
- Arthritis Care & Research
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1002/acr.25455
- Citations
- 4
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Nationwide Children's Hospital
- Canadian Institutes of Health Research