Standard-of-Care Medication Withdrawal in Patients With Obstructive Hypertrophic Cardiomyopathy Receiving Aficamten in FOREST-HCM
In FOREST-HCM, one-half of the patients with oHCM attempted downtitration and withdrawal of SoC medications while receiving aficamten treatment, with infrequent instances of resumption of SoC. Stopping and dose reduction of SoC medications were well tolerated with no adverse consequences in clinical measures of efficacy (Follow-Up, Open-Label, Research Evaluation of Sustained Treatment with Aficamten in Hypertrophic Cardiomyopathy [FOREST-HCM]; NCT04848506).
Authors
- Sherif F. Nagueh (ORCID: https://orcid.org/0000-0002-4911-8056)
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0001-8966-6906)
- Roberto Barriales‐Villa (ORCID: https://orcid.org/0000-0002-6721-3487)
- Perry Elliott (ORCID: https://orcid.org/0000-0003-3383-3984)
- Artur Oręziak (ORCID: https://orcid.org/0000-0003-3318-3643)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- Sara Saberi (ORCID: https://orcid.org/0000-0003-4473-6725)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Jenny Wei (ORCID: https://orcid.org/0009-0000-5828-5705)
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Andrew Z. Wang (ORCID: https://orcid.org/0000-0002-9781-4494)
- Albree Tower‐Rader
- Mark V. Sherrid (ORCID: https://orcid.org/0000-0003-4972-7780)
- Chiara Melloni
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Florian Rader (ORCID: https://orcid.org/0000-0003-1637-5096)
- Lisa Meng (ORCID: https://orcid.org/0000-0003-0229-1131)
- Lubna Choudhury (ORCID: https://orcid.org/0000-0003-4039-8490)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
Institutions
- Northwestern University (US)
- Cedars-Sinai Medical Center (US)
- Houston Methodist (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- University of Michigan (US)
- British Heart Foundation (GB)
- Massachusetts General Hospital (US)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Lahey Medical Center (US)
- Meyer Children's Hospital (IT)
- Centro de Investigación Biomédica en Red (ES)
- Institute of Cardiology (PL)
- Saint Luke's Hospital (US)
- Cytokinetics (United States) (US)
- Complexo Hospitalario Universitario A Coruña (ES)
- Duke University Hospital (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Instituto de Investigación Biomédica de A Coruña (ES)
- University College London (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1016/j.jacc.2024.09.002
- Citations
- 15
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.03
Funders
- Cytokinetics