Polyamine Anabolism Promotes Chemotherapy‐Induced Breast Cancer Stem Cell Enrichment (Adv. Sci. 40/2024)
Breast Cancer Stem Cells Article number 2404853 by Kai Zhang, Qi Mei, Rong Sun, Haiquan Lu, and co‐workers reveals the critical role of polyamine anabolism in chemotherapy‐induced breast cancer stem cell (BCSC) enrichment. Chemotherapy induces the transcription factor HIF‐1‐regulated ODC1 and SRM expression and activates polyamine anabolism, which finally leads to enrichment of BCSCs. This study provides a novel strategy for breast cancer treatment by identifying a novel specific HIF‐1 inhibitor, britannin, which effectively blocks chemotherapy‐induced polyamine anabolism and BCSC enrichment. [Image: see text]
Authors
- Jia Liu (ORCID: https://orcid.org/0000-0003-2755-7709)
- Jie Lan (ORCID: https://orcid.org/0000-0002-4962-8363)
- Xiaofeng Jiang (ORCID: https://orcid.org/0000-0001-9071-9307)
- Zhaojian Liu (ORCID: https://orcid.org/0000-0002-2542-0859)
- Guangyao Wei
- Zhiqun Zhao (ORCID: https://orcid.org/0000-0001-5000-100X)
- Huize Xia
- Yang You (ORCID: https://orcid.org/0000-0002-5282-375X)
- Qi Mei (ORCID: https://orcid.org/0000-0002-9826-5044)
- Kai Ji (ORCID: https://orcid.org/0000-0002-4040-0880)
- Xinlong Du (ORCID: https://orcid.org/0000-0001-8928-3630)
- Haiquan Lu (ORCID: https://orcid.org/0000-0001-6570-7208)
- Guangyu Ji
- Yuanyuan Yang (ORCID: https://orcid.org/0000-0001-7296-9222)
- Yuhong Zhang (ORCID: https://orcid.org/0009-0002-6704-5919)
- Rong Sun (ORCID: https://orcid.org/0000-0003-2356-1495)
- Yajing Zhang (ORCID: https://orcid.org/0000-0001-9930-567X)
- Huijing Feng
- Ya‐Wen Wang
- Kai Zhang (ORCID: https://orcid.org/0000-0001-6818-377X)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-1243-0177)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/advs.202470240
- Citations
- 1
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.23