Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 Immunotherapy (Adv. Sci. 40/2024)
Nanovaccine In article number 2404159, Helena F. Florindo, Ronit Satchi‐Fainaro, and co‐workers describe the development of a next‐generation thermostable multi‐epitope mannosylated nanovaccine administered intranasally. This innovative nanovaccine generates mucosal immunity while regulating PD‐1/PD‐L1 axis within the DC‐T cell interface, coordinating CD4 and CD8 T‐cell immunities and activating robust neutralizing antibody responses against SARS‐CoV‐2. This cover artwork highlights the main features of our novel delivery system: The sugar‐coated train carries the SARS‐CoV‐2 peptides cargo, while speeding on PD‐L1 siRNA tracks through the nose caves to reach the final destination‐ an effector and protective immunity. Illustration credit: Sharon Amlani. [Image: see text]
Authors
- Michael Mor (ORCID: https://orcid.org/0000-0003-1361-4151)
- Mira Toister‐Achituv
- Yulia Liubomirski
- Sarit Aviel‐Ronen (ORCID: https://orcid.org/0000-0002-9660-7979)
- Daniella Vaskovich‐Koubi (ORCID: https://orcid.org/0000-0001-7300-481X)
- Ana Zarubica (ORCID: https://orcid.org/0000-0001-5488-4137)
- Rita C. Acúrcio (ORCID: https://orcid.org/0000-0003-3412-1903)
- Natalia T. Freund (ORCID: https://orcid.org/0000-0002-5386-502X)
- Manon Fabregue
- Bárbara Carreira (ORCID: https://orcid.org/0000-0001-6382-5745)
- Carlos Araújo (ORCID: https://orcid.org/0000-0001-5202-6091)
- Ronit Satchi‐Fainaro (ORCID: https://orcid.org/0000-0002-7360-7837)
- Ana S. Viana (ORCID: https://orcid.org/0000-0001-8405-9672)
- Eilam Yeini (ORCID: https://orcid.org/0000-0003-3491-3994)
- Cárol Palma (ORCID: https://orcid.org/0000-0001-5371-7417)
- João Gonçalves (ORCID: https://orcid.org/0000-0002-1245-3715)
- Vera Ferreira (ORCID: https://orcid.org/0000-0002-3962-5476)
- Helena F. Florindo (ORCID: https://orcid.org/0000-0002-4006-5840)
- Adva Yeheskel (ORCID: https://orcid.org/0000-0002-9183-8807)
- Ron Kleiner (ORCID: https://orcid.org/0000-0002-4638-4738)
- Eran Bacharach (ORCID: https://orcid.org/0000-0001-8341-2833)
- Solene Matthieu
- Capucine Guerry
Publication Details
- Journal
- Advanced Science
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/advs.202470245
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00