Fabrication and control of magnetic planar nanorobots

With the development of science and technology, cross-scale robots are becoming increasingly popular. For different application scenarios, robots with diverse scales and functions are also required. Micron and nano scale robots are typically used for targeted drug delivery or micro signal detection in the body. In order to enable micro and nano robots to enter the tissue through the finer blood vessels in the body for efficient drug delivery and other functions, it is required that the size of the robot is small and it can be controlled accurately. We here propose an achiral planar nanorobot construction capable of stable motion in the presence of a consistent rotating magnetic field. Using nanoimprint technology, magnetic nanorobots smaller than one micron are manufactured in batches. The motion of the nanorobots is controled by Helmholtz coils which create a revolving magnetic field. The preparation accuracy, moving speed, moving accuracy and biocompatibility of the nanorobots were tested, and anti-cancer drugs were loaded on the surface of the nanorobots by means of surface modification, and the rate of drug release was subsequently evaluated. The fabrication process and magnetic control strategy of the nanorobots in this work helps the future investigations of the drug-carrying robots in body.