Pertussis seroprevalence and related factors in 15-49 years old women in Mersin, Turkey

Abstract Background Pertussis is an acute, contagious respiratory disease with high mortality and morbidity, especially in early infancy. If the mother is immune to pertussis, infants too young to be vaccinated are protected against pertussis infection after birth by maternal immunity. This study aimed to investigate pertussis seroprevalence and associated factors in women aged 15-49 years. Methods The cross-sectional study was conducted on women aged 15-49 years in Mersin city between December 2023 and February 2024. A total of 352 women from family health centres in four central districts of Mersin were included in the study. In this study, anti PT-IgG levels in blood samples were investigated by enzyme-linked immunosorbent assay ELISA method. In the analysis of the data, descriptive statistics, chi-square analysis, and binary logistic regression analysis were used. The results were presented at a 95% confidence interval, at a significance level of p < 0.05. Results Anti-PT IgG seropositivity was detected in 150 (%42.6) of the women. In seven (2%) of women, the anti-PT IgG value was greater than 100, indicating an acute infection. Individuals who did not receive or could not recall having received school vaccinations were found to be 2.18 times more likely to be seropositive than those who had received vaccinations at school. Individuals residing in the same household with a healthcare professional were found to be 1.78 times more likely to be seropositive than those who did not. Conclusions Half of our region’s newborns lack protection from whooping cough. Maternal immunization with pertussis-containing vaccines is crucial. Many countries have safely used such vaccines for years. Replacing Td with Tdap in Turkey’s pregnancy immunization can better shield mothers and newborns from pertussis. Key messages • Maternal immunization is crucial for protecting newborns from pertussis, reducing mortality and morbidity. • Addressing vaccination disparities is vital to ensure community-wide protection against pertussis, saving lives.