Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells
Estrogen receptor-positive breast cancer patients may benefit from high levels of TGFB1 expression due to the repression of estrogen receptor signaling, inhibition of proliferation, and induction of apoptosis in cancer cells. However, some TGFB1-stimulated cells may undergo EMT, which increases the risk of metastasis.
Authors
- Monika Kurpas (ORCID: https://orcid.org/0000-0001-7635-8437)
- Paweł Kuś (ORCID: https://orcid.org/0000-0002-4367-9821)
- Roman Jaksik (ORCID: https://orcid.org/0000-0003-1866-6380)
- Agnieszka Toma-Jonik (ORCID: https://orcid.org/0000-0002-9282-4925)
- Wiesława Widłak (ORCID: https://orcid.org/0000-0002-8440-9414)
- Patryk Janus (ORCID: https://orcid.org/0000-0003-2002-3499)
- Michalina Gramatyka (ORCID: https://orcid.org/0000-0002-9573-2479)
- Marek Kimmel (ORCID: https://orcid.org/0000-0001-8161-890X)
- Natalia Vydra (ORCID: https://orcid.org/0000-0001-7749-7770)
Institutions
- Silesian University of Technology (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Łukasiewicz Research Network - Institute of Welding (PL)
- Rice University (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1186/s12964-024-01821-5
- Citations
- 13
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- European Commission
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki
- European Social Fund